Refer to Exercise 18.18. Compare the mean AUCs for the three formulations using only the period 1…

Refer to Exercise 18.18. Compare the mean AUCs for the three formulations using only the period 1 data. Does this analysis confirm the analysis of Exercise 18.19? Why might the analysis of Exercise 18.19 be more suitable or not be more suitable than the “parallel” analysis of this exercise?

Exercise 18.18 and 18.19
Refer to Exercise 18.18. Run an analysis of variance for a three-period crossover design. Does your analysis confirm the intuition you expressed in Exercise 18.18? Use a  .05.

Exercise 18.18

Many of us have been exposed to advertising related to the “bioavailability” of generic and brand-name formulations of the same drug product. One way to compare the bioavailability of two formulations of a drug product is to compare areas under the concentration curve (AUC) for subjects treated with both formulations. For example, the shaded area in the figure represents the AUC for a patient treated with a single dose of a drug.

A three-period crossover design was used to compare the bioavailability of two brand-name (1 and 2) and one generic version (3) of weight-reducing agents. Three sequences of administering the drugs were used in the study:

Sequence 1: 1, 2, 3
Sequence 2: 2, 3, 1
Sequence 3: 3, 1, 2

A random sample of five subjects was assigned to each of the three sequences. The AUCs for these 15 patients are shown here.

a. Plot the formulation means (AUCs) by period for each sequence.

b. Is there evidence of a period effect?

c. Do the formulations appear to differ relative to AUC?

Calculate the price of your order

550 words
We'll send you the first draft for approval by September 11, 2018 at 10:52 AM
Total price:
The price is based on these factors:
Academic level
Number of pages
Basic features
  • Free title page and bibliography
  • Unlimited revisions
  • Plagiarism-free guarantee
  • Money-back guarantee
  • 24/7 support
On-demand options
  • Writer’s samples
  • Part-by-part delivery
  • Overnight delivery
  • Copies of used sources
  • Expert Proofreading
Paper format
  • 275 words per page
  • 12 pt Arial/Times New Roman
  • Double line spacing
  • Any citation style (APA, MLA, Chicago/Turabian, Harvard)

Our guarantees

Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.

Money-back guarantee

You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.

Read more

Zero-plagiarism guarantee

Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.

Read more

Free-revision policy

Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.

Read more

Privacy policy

Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.

Read more

Fair-cooperation guarantee

By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.

Read more
error: Content is protected !!