Refer to Exercise 18.21. a. Write a linear model for the above study. Make sure to identify all…

Refer to Exercise 18.21.

a. Write a linear model for the above study. Make sure to identify all parameters in the model.

b. Run an analysis of variance for the data in the study. Does your analysis confirm your intuition expressed in Exercise 18.21?

c. Which pairs of formulations are significantly different?

Exercise 18.21

The following study is described in Chinchilli, Schwab, and Sen (1989). The pain of angina is caused by a deficit in oxygen supply to the heart. Calcium channel blockers like verapamil will dilate blood vessels, increasing the supply of blood and oxygen to the heart. This controls chest pain—but only when used regularly. It does not stop chest pain once it starts. The research goal of the study was to assess if there was a difference in four commercial formulations of verapamil (denoted by A, B, C, and D). Twenty-six healthy male volunteers were randomly assigned to one of four treatment sequences (ABCD, BCDA, CDBA, or DABC). The study protocol required lengthy washouts between treatment periods, and, thus, it was thought that any drug carryover effects from previous time periods would be negligible. The response variable was the area under the plasma time curve (AUC), with values given in the following table.

a. Plot the formulation means (AUCs) by period for each sequence.

b. Does there appear to be evidence of a period effect?

c. Do the formulations appear to have different AUC means?

Calculate the price of your order

550 words
We'll send you the first draft for approval by September 11, 2018 at 10:52 AM
Total price:
$26
The price is based on these factors:
Academic level
Number of pages
Urgency
Basic features
  • Free title page and bibliography
  • Unlimited revisions
  • Plagiarism-free guarantee
  • Money-back guarantee
  • 24/7 support
On-demand options
  • Writer’s samples
  • Part-by-part delivery
  • Overnight delivery
  • Copies of used sources
  • Expert Proofreading
Paper format
  • 275 words per page
  • 12 pt Arial/Times New Roman
  • Double line spacing
  • Any citation style (APA, MLA, Chicago/Turabian, Harvard)

Our guarantees

Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.

Money-back guarantee

You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.

Read more

Zero-plagiarism guarantee

Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.

Read more

Free-revision policy

Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.

Read more

Privacy policy

Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.

Read more

Fair-cooperation guarantee

By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.

Read more
error: Content is protected !!