Sleep duration data (in hours/night) are shown for the patients of Exercise 18.13.
Sequence 1 received the investigational drug first and the placebo second; the reverse order applied to sequence 2.
a. Compute means and standard errors per sequence per period.
b. Plot these data to show what happened during the study. Does the investigational drug appear to affect sleep duration? In what way? Use a .05.
c. Run a repeated measures analysis of variance for this design. Draw conclusions. Does the analysis of variance confirm your impressions in part (b)?
An investigational drug product was studied under sleep laboratory conditions to determine its effect on duration of sleep. A group of 16 patients willing to participate in the study was randomly assigned to one of two drug sequences; 8 were to receive the investigational drug in period 1 and an identical-appearing placebo in period 2, and the remaining 8 patients were to receive the treatment in the reverse order.
a. Identify the design.
b. Give a model for this design.
c. State the assumptions that might affect the appropriateness of this design.
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